CDMO SERVICES FOR VIRAL VECTORS & VACCINES

Producer Cell Line Development

Get the right cell line for production of your vector and virus!

IN A NUTSHELL

Cell Lines for Viral Vector and Virus Production

In the rapidly advancing field of gene therapy and vaccine development, the production of viral vectors such as lentiviruses, adeno-associated viruses (AAV), adenoviruses, modified vaccinia Ankara (MVA), and other viruses is critical. Developing robust and efficient cell lines in-house for the production of these viral vectors offers significant advantages, especially when these cell lines are cultivated in suspension using chemically defined media.

HOW WE WORK

Quality Drives Outcome

Across Whole Viral Vectors GMP Life Cycle

Our services comprise everything from the start of your viral vectors GMP life cycle by generation of your MCB and/or MVS either from your cell line or vector platform or out of one of our established MCBs or vectors.

GMP-Compliance

Capability and Scale

Over the expansion of the cells in scales up to 200 L and the production of your vector by either transfection, producer cell line or infection based methods. Depending on the type of virus and cells we are capable of establishing contentious harvest methods over multiple days to maximize yield.

State-of-Art Technologies

Up to the downstream purification of your product with state of the art disposable systems for dead end filtration, tangential flow filtration or chromatographic purification.

Drug Product Filling

At the end of the value chain, the drug substance is refined into a drug product. Our filling process is based on a semi-automated solution (robotic support) in a class A clean room environment. We are capable of aseptically filling the drug product and required diluents into vials with the sizes 2, 6 and 20 mL with a throughput of approx. 200 - 400 vials per hour.

All on One Place

Short distances between our production facility and the quality control laboratories ensure optimal handling and analysis of sensitive viral products and intermediates.

THE PLATFORMS BEHIND IT

Hek 293 Cell Line for Unparalleled Control

At our facility, we have generated several specialized cell lines to meet diverse production needs. Most notably, our proprietary HEK293 cell line.

Our HEK293 cell line is specifically engineered for the production of lentiviruses, AAV, and adenoviruses. This cell line offers unparalleled control over the manufacturing process, ensuring consistency and quality in the final product.

Duck Cell Line for the Production of MVA and Other Vaccine Candidates

In addition to HEK293, our unique AGE1.CR.pIX^® duck cell line has been developed in-house for the production of MVA and different viral vaccine strains for human and veterinary application. This cell line is optimized to enhance yield and scalability by addressing the specific requirements of these viral vectors.

Suspension Culture Systems for More Efficiency

The use of suspension culture systems further improves production efficiency by enabling higher cell densities and facilitating easier scale-up in bioreactors.

Chemically Defined Media to Eliminate Variability

The use of chemically defined media across our cell lines eliminates the variability and potential contaminants associated with serum-based media, thereby ensuring a more predictable and reproducible environment for cell growth and virus production. This not only enhances the safety profile of the produced viral vectors and viruses, it also simplifies regulatory compliance.

This approach helps us achieve a more efficient, scalable, and high-quality production process for viral vectors, which ultimately accelerates the path from research to clinical application.

Our Promise To You

High Yield in Suspension Culture

Suspension-adapted producer cells enable scalable, high-yield production in bioreactors
This makes them ideal for large-scale viral vector and vaccine manufacturing

Consistency with Chemically Defined Medium

Growing producer cells in a chemically defined medium ensures a consistent and reproducible environment
This helps control batch variability, improve process reliability, and ensure consistent viral vector potency

Enhanced Safety and Compliance with GMP Grade Suspension Lines

Suspension-adapted, fully characterized master and working cell banks (MCBs, WCBs) in chemically defined media meet rigorous safety and regulatory standards
This supports robust production processes in essentially closed system