DirectedLuck® Transposase System for Viral Vectors
Advance your viral vector production with a leading-edge transposase system that provides the highest titer and expression stability to generate a stable packaging or producer cell line. DirectedLuck® enables the highly efficient production of viral vectors for cell and gene therapy and also speeds time to clinic!
Transposase-Based Gene Delivery for Cost-Efficient Viral Vector Production
DirectedLuck® facilitates gene delivery based on epigenetic targeting and carefully designed transposase and transposons. The technology delivers transposons specifically to integration sites with the highest transcriptional activity. Easy adjustment of gene dosage facilitates a concerted expression of viral components and target genes. This results in elevated titers, scalability, and robustness. The technology enables cost-efficient production of viral vectors and accelerates time to clinic.
Key Features
Epigenetic targeting of best genomic integration sites
Thoroughly designed transposase and transposons
Highest robustness reported from licensees
Elevated titer and outstanding stability for stable packaging and producer cells
Royalty-free
Enables Optimal Expression
DirectedLuck® makes parallel integration of large sets of viral genes feasible. Since expression is copy number dependent, a simple adjustment of gene dosage results in the concerted expression of all viral factors and target genes, thereby enabling the highest titers.
Rapid High-Titer Production System
The system is extremely robust. Stable pools of packaging or producer cells can be generated within days. Titers of these cell pools are already exceptionally high. This offers the opportunity to use producer pools directly for the production of viral vectors and CAR-Ts, which speeds time to clinic.
Our Promise to You
Rely on Fast Timelines
- One-Stop-Shop with seamless, integrated Services
- Parallel Processes
- Efficient project execution
- Do it right from the beginning
Get Your High Quality Candidate
- Scientific excellence
- Deep understanding for molecule / Long + broad experience
- Strong Analytics teams and stellar quality management services
- Enabling technologies
Have the Flexibility You Need
- Modular Offering
- Customer Centricity/ Strong Partnership Approach
- Experienced Project Managers and efficient decision-making
When to Use DirectedLuck®
Cost-efficient production of viral vectors
Highly efficient and quick generation of stable packaging cell lines
Fast generation of stable producer pools which can be used for manufacturing
Generation of high titer producer cell lines
Our Promise To You
Take the Fast Path to Clinic at a Much Lower Cost Point
- Streamlines cell line development for packaging and producer cells
- Highly productive and stable producer pools enable direct manufacturing
- Speed time to clinic by enabling robust scale-up and cut down on manufacturing costs
Achieve Superior Titer and Stability with the Utmost Robustness
- Utilize epigenetics for integration at genomic sites with the highest levels of activity
- Achieve the highest titer, stability, and robustness through superior genomic targeting and transposon elements
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Get Exceptional Product Quality
- In complex biologics with multiple chains or viral vectors, individual genes have to be balanced to achieve the highest content of the desired product
- As expression is copy number dependent, ratios of transposons used for individual protein chains or viral components can be flexibly adjusted to modulate product purity
V2 Benefits- TBD
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One-Stop-Shop with seamles, integrated Services
-
Parallel Processes
-
Efficient project execution
-
Do it right from the beginning
-
Scientific excellence
-
Deep understanding for molecule / Long + broad experience
-
Strong Analytics teams and stellar quality management services
-
Enabling technologies
-
Modular Offering
-
Customer Centricity/ Strong Partnership Approach
-
Experienced Project Managers and efficient decision making