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TECHNOLOGIES FOR VIRAL VECTORS & VACCINES

DirectedLuck® Transposase System for Viral Vectors

Advance your viral vector production with a leading-edge transposase system that provides the highest titer and expression stability to generate a stable packaging or producer cell line. DirectedLuck® enables the highly efficient production of viral vectors for cell and gene therapy and also speeds time to clinic! 

IN A NUTSHELL

Transposase-Based Gene Delivery for Cost-Efficient Viral Vector Production

DirectedLuck® facilitates gene delivery based on epigenetic targeting and carefully designed transposase and transposons. The technology delivers transposons specifically to integration sites with the highest transcriptional activity. Easy adjustment of gene dosage facilitates a concerted expression of viral components and target genes. This results in elevated titers, scalability, and robustness. The technology enables cost-efficient production of viral vectors and accelerates time to clinic. 

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Key Features

Epigenetic targeting of best genomic integration sites

Thoroughly designed transposase and transposons

Highest robustness reported from licensees

Elevated titer and outstanding stability for stable packaging and producer cells 

Flexible adjustment of gene dosage for viral factors and CARs 

Royalty-free


Protein DirectedLuck
HOW WE WORK

Enables Optimal Expression

DirectedLuck® makes parallel integration of large sets of viral genes feasible. Since expression is copy number dependent, a simple adjustment of gene dosage results in the concerted expression of all viral factors and target genes, thereby enabling the highest titers. 

Rapid High-Titer Production System

The system is extremely robust. Stable pools of packaging or producer cells can be generated within days. Titers of these cell pools are already exceptionally high. This offers the opportunity to use producer pools directly for the production of viral vectors and CAR-Ts, which speeds time to clinic. 

Our Promise to You

Rely on Fast Timelines

  • One-Stop-Shop with seamless, integrated Services
  • Parallel Processes
  • Efficient project execution
  • Do it right from the beginning

Get Your High Quality Candidate

  • Scientific excellence
  • Deep understanding for molecule / Long + broad experience
  • Strong Analytics teams and stellar quality management services
  • Enabling technologies

Have the Flexibility You Need

  • Modular Offering
  • Customer Centricity/ Strong Partnership Approach
  • Experienced Project Managers and efficient decision-making

USE CASES

When to Use DirectedLuck®

Cost-efficient production of viral vectors

Highly efficient and quick generation of stable packaging cell lines 
Fast generation of stable producer pools which can be used for manufacturing
Generation of high titer producer cell lines

Our Promise To You

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Take the Fast Path to Clinic at a Much Lower Cost Point 
  • Streamlines cell line development for packaging and producer cells 
  • Highly productive and stable producer pools enable direct manufacturing 
  • Speed time to clinic by enabling robust scale-up and cut down on manufacturing costs 
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Achieve Superior Titer and Stability with the Utmost Robustness
  • Utilize epigenetics for integration at genomic sites with the highest levels of activity 
  • Achieve the highest titer, stability, and robustness through superior genomic targeting and transposon elements

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Get Exceptional Product Quality
  • In complex biologics with multiple chains or viral vectors, individual genes have to be balanced to achieve the highest content of the desired product 
  • As expression is copy number dependent, ratios of transposons used for individual protein chains or viral components can be flexibly adjusted to modulate product purity 
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  • One-Stop-Shop with seamles, integrated Services
  • Parallel Processes
  • Efficient project execution
  • Do it right from the beginning

  • Scientific excellence

  • Deep understanding for molecule / Long + broad experience

  • Strong Analytics teams and stellar quality management services

  • Enabling technologies

  • Modular Offering

  • Customer Centricity/ Strong Partnership Approach

  • Experienced Project Managers and efficient decision making

Elevate Your Candidate With The Right CDMO

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